These are the results for the 2000 edition of the Paris–Roubaix cycling classic, in which Johan Museeuw took his second Roubaix win. This edition was raced in warm and dry conditions but with strong winds.
| Cyclist | Team | Time | |
|---|---|---|---|
| 1 | Johan Museeuw (BEL) | Mapei-Quick Step | 6h 47'00" |
| 2 | Peter Van Petegem (BEL) | Farm Frites | + 15" |
| 3 | Erik Zabel (GER) | Team Telekom | s.t. |
| 4 | Tristan Hoffman (NED) | US Postal | s.t. |
| 5 | Stefano Zanini (ITA) | Mapei-Quick Step | s.t. |
| 6 | George Hincapie (USA) | US Postal | s.t. |
| 7 | Marc Wauters (BEL) | Rabobank | s.t. |
| 8 | Franco Ballerini (ITA) | Lampre-Daikin | s.t. |
| 9 | Steffen Wesemann (GER) | Team Telekom | + 21" |
| 10 | Andrea Tafi (ITA) | Mapei-Quick Step | + 1'18" |
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